Synaptic plasticity across dendritic location.
نویسندگان
چکیده
منابع مشابه
Dendritic excitability and synaptic plasticity.
Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites play an active role in transforming synaptic input into neuronal output and in defining the relationships between active synapses. In this review, we discuss how these dendritic properties influence the rules governing the induction of synaptic plasticity. We argue that the location of synapses in the de...
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Considerable evidence suggests that the formation of long-term memories requires a critical period of new protein synthesis. Recently, the notion that some of these newly synthesized proteins originate through local translation in neuronal dendrites has gained some traction. Here, we review the experimental support for this idea and highlight some of the key questions outstanding in this area.
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In a neuron's dendritic spine, the location of CaMKII is controlled by a number of interacting factors, including its ability to bind calcium/calmodulin, its phosphorylation state and the synthesis of new subunits in the dendrites. New studies have shown that the exact location of CaMKII is crucial for the form and endurance of synaptic plasticity.
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Multiple stimulation protocols have been found to be effective in changing synaptic efficacy by inducing long-term potentiation or depression. In many of those protocols, increases in postsynaptic calcium concentration have been shown to play a crucial role. However, it is still unclear whether and how the dynamics of the postsynaptic calcium alone determine the outcome of synaptic plasticity. ...
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context the current study aimed to review research articles concerning cortical representational plasticity following the manipulations of inputs. evidence acquisition this review article compromised previous studies in pubmed, google scholar and scientific information databases according to the keywords since 1988. results ca1 neurons depolarization paired with ca3 presynaptic input result in ...
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ژورنال
عنوان ژورنال: Frontiers in Systems Neuroscience
سال: 2014
ISSN: 1662-5137
DOI: 10.3389/conf.fnsys.2014.05.00006